Lectin from Lycopersicon esculentum (tomato)
SIGMA/L0401 - FITC conjugate, buffered aqueous solution
Synonym: Lycopersicon esculentum agglutinin; LEA
Product Type: Chemical
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| conjugate | FITC conjugate |
| extent of labeling | 2.0-6.0 mol FITC per mol lectin |
| form | buffered aqueous solution |
| Quality Level | 200  |
| storage temp. | 2-8°C |
| Analysis Note: | Agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 7.3, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hour incubation at 25 °C. |
| Application: | Lectin from Lycopersicon esculentum (tomato) has been used: • for immunofluorescence staining • for the quantification of vascular perfusion • for the evaluation of gel perfusion efficiency |
| Biochem/physiol Actions: | LEA is not blood group specific, but has an affinity for N-acetyl-β- |
| Biochem/physiol Actions: | Lectin has anti-cancer, anti-human immunodeficiency virus (anti-HIV), anti-microbial infection and blocks mucosal atrophy. It reduces type 2 diabetes and obesity, stimulates nutrient absorption and drug targeting. It is used to stain the vascular tree in the spinal cord and brain of animals. Lectin agglutinates cells and precipitates polysaccharides and glycoproteins. |
| General description: | Lectins are carbohydrate binding proteins. Lectin from Lycopersicon esculentum (LEA) binds strongly to polylactosamine oligosaccharides. It is the major component of endothelial and epithelial cell surface carbohydrate. |
| Packaging: | Sold on the basis of mg active conjugate. |
| Physical form: | Solution in 10 mM HEPES, 0.15 M NaCl, pH 7.5, containing 0.1 mM Ca2+, 0.08% sodium azide and 5 mg/mL β-cyclodextrin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |