Monoclonal Anti-Leukemia Inhibitory Factor antibody produced in mouse
SIGMA/L0669 - clone 9824, purified immunoglobulin, lyophilized powder
Synonym: Anti-CDF; Anti-Cholinergic differentiation factor; Anti-HILDA; Anti-LIF
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 9824, monoclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | capture ELISA: 2-4 μg/mL |
| immunohistochemistry: 25 μg/mL | |
| neutralization: suitable | |
| western blot: 1-2 μg/mL | |
| UniProt accession no. | P15018  |
| Biochem/physiol Actions: | Leukemia inhibitory factor (LIF) is a pleotrophic glycoprotein that belongs to the IL-6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-c Fos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic cell differentiation. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | purified, E. coli-derived recombinant human leukemia inhibitory factor. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |