Anti-phospho-5-Lipoxygenase (pSer523) antibody produced in rabbit
SIGMA/L1168 - affinity isolated antibody, buffered aqueous glycerol solution
MDL Number: MFCD08705494
Product Type: Chemical
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| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| Quality Level | 200  |
| shipped in | wet ice |
| species reactivity | human, rat |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer523) |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable |
| immunoprecipitation (IP): suitable | |
| indirect immunofluorescence: suitable | |
| western blot: 1:1,000 | |
| UniProt accession no. | P09917  |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunohistochemistry (1 paper) |
| Biochem/physiol Actions: | The gene ALOX5 (arachidonate 5-lipoxygenase) encodes a lipoxygenase that catalyzes the conversion of arachidonic acid (AA) and other fatty acids to bioactive compounds, such as 5(S)-hydroxyeicosatetraen |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The gene ALOX5 (arachidonate 5-lipoxygenase), also referred to as 5-LOX (5-lipoxygenase), encodes a protein belonging to the lipoxygenase family. The gene is mapped to human chromosome 10q11.21. The protein contains a distinct ‘C2-like’ domain at the amino terminal that is involved in Ca2+-dependent membrane binding and a large catalytic domain containing the non-heme catalytic iron. It is highly unstable with short-lived activity. |
| Immunogen: | phosphopeptide corresponding to amino acid residues surrounding the pSer523 of human 5-lipoxgenase (5-LO). |
| Physical form: | Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |