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Lamivudine

SIGMA/L1295 - ≥98% (HPLC), powder

Synonym: 2′,3′-Dideoxy-3′-thiacytidine; 3TC; Epivir; Epivir-HBV; Heptovir; Zeffix

CAS Number: 134678-17-4
Empirical Formula (Hill Notation): C8H11N3O3S
Molecular Weight: 229.26
MDL Number: MFCD00869739
Linear Formula: C8H11N3O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L1295-10MG 10 mg
 $101.00
1/EA		 Add To Favorites
45-L1295-50MG 50 mg
 $424.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
InChI key JTEGQNOMFQHVDC-NKWVEPMBSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string NC1=NC(=O)N(C=C1)[C@@H]2CS[C@H](CO)O2
solubility water: 10 mg/mL, clear
storage temp. room temp
Application: Lamivudine has been used to deplete the Hepatitis B Virus (HBV) covalently closed circular DNA (cccDNA) forms for the preparation of inverse nested PCR.
Biochem/physiol Actions: Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).
Biochem/physiol Actions: Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.
Features and Benefits: This compound is a featured product for ADME Tox research. Click here  to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
Symbol GHS08  GHS08
Signal word Warning
Hazard statements H361
Precautionary statements P281
Risk Statements 63
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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