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LY255283

SIGMA/L1920 - ≥98% (HPLC), powder

Synonym: 1-(5-Ethyl-2-hydroxy-4-(6-methyl-6-(1H-tetrazol-5-yl)heptyloxy)phenyl)ethanone

CAS Number: 117690-79-6
Empirical Formula (Hill Notation): C19H28N4O3
Molecular Weight: 360.45
MDL Number: MFCD00876422
Linear Formula: C19H28N4O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L1920-5MG 5 mg
 $183.00
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assay ≥98% (HPLC)
color off-white to light yellow
form powder
InChI 1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23)
InChI key WCGXJPFHTHQNJL-UHFFFAOYSA-N
originator Eli Lilly
Quality Level 100 
SMILES string CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c2nnn[nH]2
solubility DMSO: >20 mg/mL
storage temp. −20°C
Application: LY255283, a competitive leukotriene B4 receptor antagonist, is used in leukotriene receptor research along with other selective leukotriene receptor agonists and antagonist to identify and differentiate the physiological and cell signaling effects of the leukotriene B4 receptor on processes such as paclitaxel resistance in MCF-7/DOX breast cancer cells, monocyte-derived dendritic cell chemotaxis, and 5-lipoxygenase activity and interleukin-8 production in human neutrophils. LY255283 may be used to help verify that an observed process or cell event is leukotriene B4 receptor-dependent.
Biochem/physiol Actions: LY255283 is a competitive leukotriene B4 receptor antagonist, specific to the BLT2 receptor subtype.
Biochem/physiol Actions: LY255283 is a competitive leukotriene B4 receptor antagonist, with an IC50 of about 100 nM. It is somewhat selective for the BLT2 receptor, since IC50 values at the BLT1 receptor are >10 μM. LY255283 reduces airway obstruction in animal models of asthma.
Features and Benefits: This compound was developed by Eli Lilly . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352204

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