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L-165,041

SIGMA/L2167 - ≥98% (HPLC), powder

Synonym: 4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy­acetic acid

CAS Number: 79558-09-1
Empirical Formula (Hill Notation): C22H26O7
Molecular Weight: 402.44
MDL Number: MFCD04974501
Linear Formula: C22H26O7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L2167-5MG 5 mg
 $235.00
1/EA		 Add To Favorites
45-L2167-25MG 25 mg
 $678.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color off-white
form powder
InChI 1S/C22H26O7/c1-3-5-19-20(11-10-18(15(2)23)22(19)26)28-13-4-12-27-16-6-8-17(9-7-16)29-14-21(24)25/h6-11,26H,3-5,12-14H2,1-2H3,(H,24,25)
InChI key HBBVCKCCQCQCTJ-UHFFFAOYSA-N
mp 127-128 °C (lit.)
originator GlaxoSmithKline
Quality Level 100 
SMILES string CCCc1c(O)c(ccc1OCCCOc2ccc(OCC(O)=O)cc2)C(C)=O
solubility DMSO: >10 mg/mL
storage condition protect from light
  under inert gas
storage temp. 2-8°C
Application: L-165,041 has been used as a peroxisome proliferator-activated receptor β/δ (PPARβ/δ) ligand to study its influence on PPARβ/δ mediated postnatal myogenesis in C2C12 myoblasts.
Biochem/physiol Actions: L-165041 dose-dependently blocks rat vascular smooth muscle cell (VSMC) proliferation and migration by inducing the cell cycle arrest. It has the potential to treat pathological cardiovascular conditions, such as restenosis and atherosclerosis. L-165041 also effectively inhibits the progression of diabetic nephropathy. It exhibits anti-apoptosis and anti-angiogenic effects.
Biochem/physiol Actions: PPARβ (PPARδ) selective agonist.
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
mp 127-128 °C (lit.)
Storage Temp. 2-8°C
UNSPSC 12352200

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