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LY225910

SIGMA/L2545 - ≥98% (HPLC)

Synonym: 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy )phenyl]-4-(3H)-quinazolinone

CAS Number: 133040-77-4
Empirical Formula (Hill Notation): C27H24BrN3O2
Molecular Weight: 502.40
MDL Number: MFCD00907856
Linear Formula: C27H24BrN3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L2545-25MG 25 mg
 $366.00
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assay ≥98% (HPLC)
color off-white
form powder
InChI 1S/C27H24BrN3O2/c1-17(2)33-21-7-5-6-20(15-21)31-26(30-25-9-4-3-8-22(25)27(31)32)13-10-18-16-29-24-12-11-19(28)14-23(18)24/h3-9,11-12,14-17,29H,10,13H2,1-2H3
InChI key KUECXUACQOYKNB-UHFFFAOYSA-N
originator Eli Lilly
Quality Level 100 
SMILES string CC(C)Oc1cccc(c1)N2C(CCc3c[nH]c4ccc(Br)cc34)=Nc5ccccc5C2=O
solubility DMSO: >20 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: Cholecystokinin is expressed in the gastrointestinal tract and the central nervous system. Cholecystokinin receptor type 2 (CCK2) is a GPCR that is highly expressed in brain and spinal cord. CCK2 is implicated in many brain processes, including mood, anxiety, and pain, through its modulation of GABA neurotransmission.

LY225910 is a potent, selective CCK2 antagonist. LY225910 blocks agonism of CCK2 by CCK-8S, the peptide agonist. LY225910 has been measured in multiple systems, including GABA efflux from cortical cultures, depolarization of spinal cord neurons (via potassium conductance), modulation of excitatory postsynaptic potentials (EPSPs) in nucleus accumbens slices, and enhancement of morphine analgesia.
Biochem/physiol Actions: LY 225910 is a potent, selective CCK2 antagonist.
Features and Benefits: This compound is featured on the Cholecystokinin and Gastrin Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Eli Lilly . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301 - H413
Precautionary statements P273 - P301 + P310 + P330
Hazard Codes Xn
Risk Statements 22
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) 638.6 - 762.1 °F
Flash Point(C) 337 - 405.6 °C
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352202

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