Lomefloxacin hydrochloride
SIGMA/L2906
Synonym: 1-
CAS Number: 98079-52-8
Empirical Formula (Hill Notation): C17H19F2N3O3 · HCl
Molecular Weight: 387.81
MDL Number: MFCD00214312
Linear Formula: C17H19F2N3O3 · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: L2906-10G
This image depicts SKU: L2906-10G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: L2906-1G
This image depicts SKU: L2906-1G
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| biological source | synthetic |
| color | white to off-white |
| InChI | 1S/C17H19F2N3O3.ClH/c1-3- |
| InChI key | KXEBLAPZMOQCKO-UHFFFAOYSA |
| mode of action | DNA synthesis | interferes |
| enzyme | inhibits | |
| Quality Level | 200  |
| SMILES string | Cl.CCN1C=C(C(O)=O)C(=O)c2 |
| storage temp. | −20°C |
| Application: | Lomefloxacin is a fluoroquinolone antibiotic that is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, H. influenzae, S. aureus, P. aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice and modification of the kinetics of growth of Gram-negative bacteria. |
| Biochem/physiol Actions: | Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. |
| General description: | Chemical structure: fluoroquinolone |
| Packaging: | 1, 10 g in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Storage Temp. | −20°C |
| UNSPSC | 51282927 |