Synonym: 4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1- piperazinehexanamide hydrochloride
Empirical Formula (Hill Notation): C32H39N3O·HCl · xH2O
Molecular Weight: 518.13 (anhydrous basis)
MDL Number: MFCD11114387
Linear Formula: C32H39N3O·HCl · xH2O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
off-white |
| form |
solid |
| InChI |
1S/C32H39N3O.ClH.H2O/c36-32(33-30-18-11-15-26-14-6-7-16-28(26)30)20-5-2-10-21-34-22-24-35(25-23-34)31-19-9-8-17-29(31)27-12-3-1-4-13-27;;/h1,3-4,6-9,12-14,16-17,19,30H,2,5,10-11,15,18,20-25H2,(H,33,36);1H;1H2 |
| InChI key |
VOKWUIAIZYWMDR-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
O.Cl.O=C(CCCCCN1CCN(CC1)c2ccccc2-c3ccccc3)NC4CCCc5ccccc45 |
| solubility |
DMSO: >5 mg/mL |
| |
H2O: 6 mg/mL |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
LP 12 dihydrochloride is a 5-HT7 is a receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors. |
| Biochem/physiol Actions: |
LP 12 dihydrochloride is a 5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.13, 224, 60.9 and 1464 nM, respectively. It also displays selectivity over D2, 1723; over 5-HT1A, 468; over 5-HT2A, 11261; and high potency. Sigma has added LP 44 (L9793) which shows significantly lower D2 selectivity (7.3 nM/0.22 nM for 33-fold), lower selectivity over 5-HT1A, 240; and over 5-HT2A, 1482. LP 12 and LP 44 seem to share a common intermediate. |
| Packaging: |
10, 50 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
