[des-Gly¹⁰, D-Ala⁶]-LH-RH ethylamide acetate salt hydrate

SIGMA/L4513 - ≥97% (HPLC), powder

Synonym: Ethylamide Acetate; Ethylamide Acetate Salt; des-Gly¹⁰ LH-RH

Empirical Formula (Hill Notation): C₅₆H₇₈N₁₆O₁₂ · xC₂H₄O₂ · yH₂O
Molecular Weight: 1167.32 (anhydrous free base basis)
MDL Number: MFCD11046043
Linear Formula: C₅₆H₇₈N₁₆O₁₂ · xC₂H₄O₂ · yH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-L4513-1MG	1 mg	$104.00 1/EA	Add To Favorites
45-L4513-5MG	5 mg	$363.00 1/EA	Add To Favorites
45-L4513-25MG	25 mg	$1400.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
form	powder
InChI	1S/C56H78N16O12.C2H4O2.H2O/c1-5-60-54(83)45-13-9-21-72(45)55(84)39(12-8-20-61-56(57)58)66-50(79)40(22-30(2)3)67-47(76)31(4)64-49(78)41(23-32-14-16-35(74)17-15-32)68-53(82)44(28-73)71-51(80)42(24-33-26-62-37-11-7-6-10-36(33)37)69-52(81)43(25-34-27-59-29-63-34)70-48(77)38-18-19-46(75)65-38;1-2(3)4;/h6-7,10-11,14-17,26-27,29-31,38-45,62,73-74H,5,8-9,12-13,18-25,28H2,1-4H3,(H,59,63)(H,60,83)(H,64,78)(H,65,75)(H,66,79)(H,67,76)(H,68,82)(H,69,81)(H,70,77)(H,71,80)(H4,57,58,61);1H3,(H,3,4);1H2/t31-,38+,39+,40+,41+,42+,43+,44+,45+;;/m1../s1
InChI key	YEEHIOYEWOESQR-PFHUABGLSA-N
Quality Level	100
SMILES string	O.CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@@H]6CCC(=O)N6
storage temp.	−20°C
UniProt accession no.	P01148
	P13562
	P30968
	Q01776

Amino Acid Sequence:	Glp-His-Trp-Ser-Tyr-Ala-Leu-Arg-Pro-NHEt
Application:	[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate has been used: • as an luteinizing hormone-releasing hormone (LHRH) agonist to synchronize a cohort of females rats • to synchronize naturally cycling rats • to induce ovulation as a gonadotropin-releasing hormone (GnRH) analogue and as a supplement in Galap extender to dilute qualified ejaculate
Biochem/physiol Actions:	Potent LH-RH agonist in rats and mice; reversibly delays sexual maturation in rats, stimulates spawning activity in fish. GnRH ( gonadotropin-releasing hormone, Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS08
Signal word	Danger
Hazard statements	H360
Precautionary statements	P201 - P308 + P313
Hazard Codes	T
Risk Statements	60
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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