Loperamide hydrochloride

SIGMA/L4762

Synonym: 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride

CAS Number: 34552-83-5
Empirical Formula (Hill Notation): C₂₉H₃₃ClN₂O₂ · HCl
Molecular Weight: 513.50
EC Number: 252-082-4
MDL Number: MFCD00058581
Linear Formula: C₂₉H₃₃ClN₂O₂ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-L4762-5G	5 g	$171.00 1/EA	Add To Favorites
45-L4762-25G	25 g	$675.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

InChI	1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H
InChI key	PGYPOBZJRVSMDS-UHFFFAOYSA-N
originator	Johnson & Johnson
Quality Level	200
SMILES string	Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4

Application:	Loperamide hydrochloride (HCl) has been used in inflammatory pain experiments and to assess the functionality of proteins. 54
Biochem/physiol Actions:	Loperamide hydrochloride (HCl) is a non-selective Ca²⁺ channel blocker. At nanomolar concentrations, it binds to μ-opioid receptors. Loperamide HCl does not cross the blood-brain barrier.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Preparation Note:	Slightly soluble in water and dilute acids, freely soluble in methanol and in chloroform, soluble in ethanol (95%).

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P264 - P270 - P301 + P310 + P330 - P405 - P501
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3

UNSPSC

12352200

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