Levosimendan

SIGMA/L5545 - ≥98% (HPLC)

Synonym: (-)-OR-1259; (R)-Simendan; 2-[2-[4-[(4R)-1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]-propanedinitrile; OR 1259; R)-((4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono) propanedintrile

CAS Number: 141505-33-1
Empirical Formula (Hill Notation): C₁₄H₁₂N₆O
Molecular Weight: 280.28
MDL Number: MFCD00867135
Linear Formula: C₁₄H₁₂N₆O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-L5545-10MG	10 mg	$92.70 1/EA	Add To Favorites
45-L5545-50MG	50 mg	$375.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow
form	powder
InChI	1S/C14H12N6O/c1-9-6-13(21)19-20-14(9)10-2-4-11(5-3-10)17-18-12(7-15)8-16/h2-5,9,17H,6H2,1H3,(H,19,21)/t9-/m1/s1
InChI key	WHXMKTBCFHIYNQ-SECBINFHSA-N
optical activity	[α]/D -500 to -650°, c = 0.5 in THF
Quality Level	100
SMILES string	C[C@@H]1CC(=O)NN=C1c2ccc(NN=C(C#N)C#N)cc2
solubility	DMSO: ≥20 mg/mL
storage temp.	room temp

Application:	Levosimendan has been used for screening its anti-human immunodeficiency virus type 1 (HIV-1) property. It has also been used for screening its cytotoxic effects in TP53 mutant and wild-type lung adenocarcinoma cell lines
Biochem/physiol Actions:	Levosimendan has a potential to inhibit both acute human immunodeficiency virus type 1 (HIV-1) replication and the reactivation of latent HIV-1 proviruses. Therefore, it is considered to be a promising anti-HIV-1 agent.
Biochem/physiol Actions:	Levosimendan is a calcium sensitiser.
Biochem/physiol Actions:	Levosimendan is a calcium sensitiser. The compound increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan binds to cardiac troponin C in a calcium-dependent manner and stabilizes troponin C. This is followed by actin-myosin cross-bridges, without increasing myocardial consumption of ATP. Additionally the compound acts as vasodilator by opening an ATP-sensitive potassium channels. Levosimendan is a drug used for treatment of congestive heart failure. Also it can be used to treat calcium channel blocker overdose.
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H312 - H332
Precautionary statements	P280
Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352202

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