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LY-364947

SIGMA/L6293 - ≥98% (HPLC)

Synonym: 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline; HTS 466284; Transforming Growth Factor-β Type I Receptor Kinase Inhibitor

CAS Number: 396129-53-6
Empirical Formula (Hill Notation): C17H12N4
Molecular Weight: 272.30
MDL Number: MFCD00800758
Linear Formula: C17H12N4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L6293-5MG 5 mg
 $215.00
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45-L6293-25MG 25 mg
 $835.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
InChI key IBCXZJCWDGCXQT-UHFFFAOYSA-N
Quality Level 100 
SMILES string c1ccc(nc1)-c2n[nH]cc2-c3ccnc4ccccc34
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC50 = 59 nM. It is much less potent at related kinases, with IC50 = 400 nM for TGF-β RII and IC50 = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and closely related to TGF-β RII. LY-364947 inhibits TGF-β-dependent cellular growth (IC50 = 81 nM) in NIH 3T3 mouse fibroblasts.
Biochem/physiol Actions: Transforming Growth Factor-β Type I receptor kinase (ALK5) inhibitor
Packaging: 5, 25 mg in glass bottle
Hazard Codes T,N
Risk Statements 25-36/37/38-50/53
Safety Statements 26-45-60-61
RIDADR UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s.,
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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