Lomerizine dihydrochloride
SIGMA/L6295 - ≥98% (HPLC), powder
Synonym: 1-
CAS Number: 101477-54-7
Empirical Formula (Hill Notation): C27H30F2N2O3·2HCl
Molecular Weight: 541.46
MDL Number: MFCD01703867
Linear Formula: C27H30F2N2O3·2HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C27H30F2N2O3.2ClH/c1-3 |
| InChI key | LOGVKVSFYBBUAJ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl.Cl.COc1ccc(CN2CCN(CC2) |
| solubility | DMSO: ≥30 mg/mL |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator. |
| Biochem/physiol Actions: | Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator. It is one of the most selective calcium channel blockers for the CNS and cerebral arteries. It has been reported to inhibit both T-type and L-type Ca2+ currents in rat hippocampal CA1 pyramidal neurons, to prevent glutamate-induced neurotoxicity in rat hippocampal primary cell cultures, and to exhibit protective effects in animal models of migraine, ischemia and hypoxia. In Japan, lomerizine has been used as the first-line prophylactic drug for migraines. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302 - H410 |
| Precautionary statements | P273 - P301 + P312 + P330 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |