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Lomerizine dihydrochloride

SIGMA/L6295 - ≥98% (HPLC), powder

Synonym: 1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride

CAS Number: 101477-54-7
Empirical Formula (Hill Notation): C27H30F2N2O3·2HCl
Molecular Weight: 541.46
MDL Number: MFCD01703867
Linear Formula: C27H30F2N2O3·2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L6295-10MG 10 mg
 $91.80
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45-L6295-50MG 50 mg
 $364.00
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assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H
InChI key LOGVKVSFYBBUAJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Cl.COc1ccc(CN2CCN(CC2)C(c3ccc(F)cc3)c4ccc(F)cc4)c(OC)c1OC
solubility DMSO: ≥30 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator.
Biochem/physiol Actions: Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator. It is one of the most selective calcium channel blockers for the CNS and cerebral arteries. It has been reported to inhibit both T-type and L-type Ca2+ currents in rat hippocampal CA1 pyramidal neurons, to prevent glutamate-induced neurotoxicity in rat hippocampal primary cell cultures, and to exhibit protective effects in animal models of migraine, ischemia and hypoxia. In Japan, lomerizine has been used as the first-line prophylactic drug for migraines.
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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