Letrozole
SIGMA/L6545 - ≥98% (HPLC)
Synonym: 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
CAS Number: 112809-51-5
Empirical Formula (Hill Notation): C17H11N5
Molecular Weight: 285.30
MDL Number: MFCD00866241
Linear Formula: C17H11N5
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C17H11N5/c18-9-13-1-5- |
| InChI key | HPJKCIUCZWXJDR-UHFFFAOYSA |
| originator | Novartis |
| Quality Level | 100  |
| SMILES string | N#CC(C=C1)=CC=C1C(N2C=NC= |
| solubility | DMSO: >50 mg/mL |
| storage temp. | 2-8°C |
| Application: | Letrozole has been used: • in organoid growth assay to determine its inhibitory capacity(48) • to investigate steroid receptor coactivator-1 (SRC-1) mediated endogenous estrogen regulation of hippocampal PSD-95(49) • to determine its effects on tumor-induced hyperalgesia(50) • for hormonal manipulation in rats(51) • to study its effects on lipocalin-2 (Lcn2)(52) • to determine its effects on mechanical hyperalgesia and aromatase expression(53) |
| Biochem/physiol Actions: | Letrozole acts as an adjuvant agent and is used to treat breast cancer. |
| Biochem/physiol Actions: | Letrozole is a non-steroidal aromatase inhibitor. |
| Biochem/physiol Actions: | Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. |
| Features and Benefits: | This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H361fd - H373 |
| Precautionary statements | P202 - P260 - P280 - P308 + P313 - P405 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 51111800 |