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LFM-A13

SIGMA/L6920 - ≥98% (HPLC), powder

Synonym: α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide; (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide; a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide

CAS Number: 244240-24-2
Empirical Formula (Hill Notation): C11H8Br2N2O2
Molecular Weight: 360.00
MDL Number: MFCD09878279
Linear Formula: C11H8Br2N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L6920-5MG 5 mg
 $105.00
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assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)/b8-6-
InChI key UVSVTDVJQAJIFG-VURMDHGXSA-N
Quality Level 100 
SMILES string CC(O)=C(/C#N)C(=O)Nc1cc(Br)ccc1Br
solubility DMSO: ≥19 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: LFM-A13 is a potent and selective inhibitor of Bruton′s tyrosine kinase (BTK)
Biochem/physiol Actions: LFM-A13 is an inhibitor of the nonreceptor tyrosine kinase Bruton′s tyrosine kinase (Btk), a new molecular target for treatment of B-cell lymphoma and autoimmune disorders. LFMA13 inhibited recombinant BTK with an IC50 value of 2.5microM with 100-fold lower inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and CDK1, 2 and 3, as well as several other related kinases
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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