α-Lactalbumin from human milk
SIGMA/L7269 - ≥95% (SDS-PAGE), lyophilized powder
CAS Number: 9051-29-0
MDL Number: MFCD00130492
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| biological source | human milk |
| concentration | >75 % protein (UV) |
| form | lyophilized powder |
| mol wt | 14,070 Da by calculation |
| Quality Level | 200  |
| solubility | H2O: soluble 10 mg/mL(lit.) |
| storage temp. | −20°C |
| technique(s) | cell migration: suitable |
| UniProt accession no. | P00709  |
| Application: | α-Lactalbumin (α-LA) has been used as a standard • to study the partitioning behavior of different monomeric proteins with exposure to amino acids on the protein surface • to study the interaction between α-LA and cathepsin D • to study the ability of breast milk fractions to enhance the transepithelial flux of extrinsic iron in colon carcinoma cell line |
| Biochem/physiol Actions: | Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. |
| Biochem/physiol Actions: | Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. Complexes of α-lactalbumin with oleic acid show drastically different activities than α-lactalbumin alone, being strongly cytotoxic to tumor cells. The complex is referred to as HAMLET (human alpha-lactalbumin made lethal to tumor cells). |
| Biochem/physiol Actions: | α-Lactalbumin (α-LA) forms a complex with lactose synthase within the mammary gland and plays a role in milk production and regulates milk volume. It acts as an essential source for bioactive peptides and essential amino acids such as lysine, tryptophan, branched-chain amino acids, and sulfur-containing amino acids that play a role in an infant′s nutrition. In addition, α-LA has a wide range of applications including a supplement to foster gastrointestinal health and modulate sleep and depression. α-LA also shows therapeutic effects against sarcopenia, seizures, mood disorders, and cancer. It has a Ca2+ binding site that binds with Na+, K+, Mg2+, and Mn2+ and many Zn2+ binding sites. |
| General description: | α-Lactalbumin (α-LA) is a small, acidic, whey protein that constitutes about 22% of the total proteins in human milk. It is produced by the epithelial cells of the mammary gland. α-LA is made up of two domains, a large α-helical domain, and a small β-sheet domain. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |