Concanavalin A from Canavalia ensiformis (Jack bean)

SIGMA/L7647 - Type VI, lyophilized powder

Synonym: Con A

CAS Number: 11028-71-0
EC Number: 234-258-2
MDL Number: MFCD00071069
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-L7647-25MG	25 mg	$35.90 1/EA	Add To Favorites
45-L7647-100MG	100 mg	$104.00 1/EA	Add To Favorites
45-L7647-250MG	250 mg	$175.00 1/EA	Add To Favorites
45-L7647-1G	1 g	$564.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: L7647-100MG

Properties
Descriptions
Safety Info.
Basic Data

biological source	Canavalia ensiformis
form	lyophilized powder
impurities	Carbohydrate, essentially free
	salt, essentially free
potency	≤20 μg per mL agglutination activity
Quality Level	200
solubility	water: 1 % (w/v)
storage temp.	−20°C
type	Type VI

Analysis Note:	Agglutination activity: Determined from serial dilutions of a 1 mg/mL solution (this activity is the lowest conc. to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C). Requires Type A Human Blood.
Application:	Concanavalin A from Canavalia ensiformis (Jack bean) has been used for developing zwitterion-immobilized molecularly imprinted polymers (ziMIPs) for protein crystallization. It has been also used in the preparation of protein loaded microgels to prevent enzymatic degradation of microgels for monitoring by confocal laser scanning microscope (CLSM).
Biochem/physiol Actions:	Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca²⁺ and Mn²⁺ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.
Packaging:	1 g in poly bottle
Packaging:	25, 100, 250 mg in poly bottle
Preparation Note:	Highly purified by specific affinity chromatography.

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334 - H361
Precautionary statements	P201 - P202 - P280 - P302 + P352 - P304 + P340 + P312 - P308 + P313
Hazard Codes	Xn
Risk Statements	63-42/43
Safety Statements	24/25-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352202

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