Lipopolysaccharides from Salmonella typhosa
SIGMA/L7895 - γ-irradiated, BioXtra, suitable for cell culture
Synonym: LPS
MDL Number: MFCD00131520
Product Type: Chemical
Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.
| biological source | bacterial (Salmonella typhosa) |
| color | white to faint yellow |
| form | lyophilized powder |
| impurities | <1% Protein (Lowry) |
| product line | BioXtra |
| purified by | gel-filtration chromatography |
| Quality Level | 200  |
| solubility | water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow |
| sterility | γ-irradiated |
| storage temp. | 2-8°C |
| technique(s) | cell culture | mammalian: suitable |
| Application: | Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs). |
| Application: | Lipopolysaccharides from Salmonella typhosa are used in cell culture and cell binding applications. The role of LPS in the secretion of TNF-α and IL-6 was studied in mouse spleen cell culture. It was used to study the role of inflammatory responses in multiple sclerosis. |
| Biochem/physiol Actions: | Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs). |
| Other Notes: | To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352201 |