L-Leucine
SIGMA/L8912 - from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Synonym: (S)-Leucine; (S)
CAS Number: 61-90-5
Empirical Formula (Hill Notation): C6H13NO2
Molecular Weight: 131.17
EC Number: 200-522-0
MDL Number: MFCD00002617
Linear Formula: (CH3)2CHCH2CH(NH2)CO2H
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: L8912-100G
This image depicts SKU: L8912-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: L8912-25G
This image depicts SKU: L8912-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: L8912-1KG
This image depicts SKU: L8912-1KG
| agency | meets EP testing specifications |
| meets JP testing specifications | |
| meets USP testing specifications | |
| USP/NF | |
| application(s) | peptide synthesis pharmaceutical (small molecule) |
| assay | 98.5-101.0% |
| biological source | non-animal source |
| cation traces | As: ≤1 ppm |
| Fe: ≤10 ppm | |
| heavy metals: ≤10 ppm | |
| NH4+: <0.02% | |
| color | white |
| form | powder |
| functional group | amine |
| carboxylic acid | |
| impurities | endotoxin, tested |
| InChI | 1S/C6H13NO2/c1-4(2)3-5(7) |
| InChI key | ROHFNLRQFUQHCH-YFKPBYRVSA |
| mp | >300 °C (lit.) |
| optical activity | [α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl |
| [α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl | |
| quality | meets EP, JP, USP testing specifications |
| Quality Level | 300  |
| SMILES string | CC(C)C[C@H](N)C(O)=O |
| solubility | 1 M HCl: 50 mg/mL |
| storage temp. | room temp |
| technique(s) | cell culture | mammalian: suitable |
| Application: | • as a hypertrophic agent to monitor its effects on myotubes. • as a component of PMG media for culturing yeast. • in myotube protein synthesis analysis in skeletal muscle cells. • to study its effects on hepatic lipid metabolism. |
| Biochem/physiol Actions: | Leucine plays a role in intracellular signaling, gene transcription, and translation. It promotes the synthesis of protein by activating the mammalian target of the rapamycin (mTOR) signaling pathway in placental cells, skeletal muscles, and adipose tissue. Leucine inhibits protein degradation and promotes mitochondrial biogenesis, glucose metabolism, and fatty acid oxidation to provide energy for protein synthesis. |
| General description: | Leucine is a non-glucogenic, and essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. |
| Other Notes: | For additional information on our range of Biochemicals , please complete this form . |
| Other Notes: | The product is intended for laboratory use only, and it is not suitable for drug, household, or other purposes. |
| Packaging: | 1 kg in poly bottle |
| Packaging: | 10 mg in glass bottle |
| Packaging: | 25, 100 g in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Purity | 98.5-101.0% |
| mp | >300 °C (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12352209 |