Luteolin

SIGMA/L9283 - ≥98% (TLC), powder

Synonym: 3′,4′,5,7-Tetrahydroxyflavone

CAS Number: 491-70-3
Empirical Formula (Hill Notation): C₁₅H₁₀O₆
Molecular Weight: 286.24
EC Number: 207-741-0
MDL Number: MFCD00017309
Linear Formula: C₁₅H₁₀O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-L9283-10MG	10 mg	$162.00 1/EA		Add To Favorites
45-L9283-50MG	50 mg	$549.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
color	yellow
form	powder
InChI	1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
InChI key	IQPNAANSBPBGFQ-UHFFFAOYSA-N
mp	~330 °C (lit.)
Quality Level	200
shelf life	3 yr
SMILES string	Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccc(O)c(O)c3
storage temp.	2-8°C

Application:	Luteolin has been used: • to induce and elucidate the apoptotic pathway in renal cell carcinoma 786-O cells • as an additive in M9 minimal medium to induce nodF gene expression • as a reference standard to qualitatively and quantitatively analyse luteolin using reverse phase-high performance liquid chromatography with diode array detector (RP-HPLC-DAD) • as a reaction supplement for β-galactosidase assay • to elucidate the anti-inflammatory efficacy of luteolin in pseudorabies virus infected RAW264.7 cell line by measuring the anti-inflammatory mediators production and also cell viability and cytotoxicity assay
Biochem/physiol Actions:	Hydroxylated flavone derivative, a strong antioxidant and radical scavenger. Suggested to play a role in prevention of cancer, possibly via the inhibition of fatty acid synthase activity.
General description:	Luteolin (3′,4′,5′,7′-tetrahydroxyflavone), a polyphenolic compound belongs to flavones subclass of flavonoids. Luteolin is commonly found in plants like celery, green peppers and chamomile tea. Luteolin is one of the major flavonoids present in the flower extract of Hieracium pannosum Boiss, aerial part of Dracocephalum kotschyi, and contributes to the antioxidant potential of the plant. Luteolin possesses antioxidant, anti-inflammatory properties, and exerts anti-tumor potential primarily through apoptosis. Luteolin exerts its apoptotic activity through downregulation of protein kinase B (Akt) pathway leading to caspase mediated apoptosis. Luteolin also resensitizes cancer cells to therapeutics. Luteolin regulates the inflammatory genes and reduces nitric oxide and inflammatory cytokine production. The anti-inflammatory property of luteolin implicates it as a potential therapeutic agent for the neurodegenerative disease like Alzheimer′s disease. In plants, luteolin induces nodulation protein F (nodF) gene.

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
mp	~330 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	12352200

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