D-Lactic Dehydrogenase from Staphylococcus epidermidis
SIGMA/L9636 - lyophilized powder, ≥80 units/mg solid
Synonym: Lactate; (R)-Lactate:NAD+ oxidoreductase; D-LDH
CAS Number: 9028-36-8
EC Number: 232-829-0
MDL Number: MFCD00130907
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: L9636-25KU
| biological source | bacterial (Staphylococcus epidermidis) |
| form | lyophilized powder |
| Quality Level | 200  |
| specific activity | ≥80 units/mg solid |
| storage temp. | −20°C |
| Application: | D-Lactic Dehydrogenase can be used to generate inhibitors of angiotensin converting enzyme by catalyzing the production of the intermediate (R)-2-Hydroxy-4-phenylbut |
| Application: | D-Lactic Dehydrogenase from Staphylococcus epidermidis has been used in the analysis of D-lactic acid. |
| Application: | D-Lactic dehydrogenase has been used in a study to assess mechanisms of active transport in isolated membrane vesicles. It has also been used in a study to investigate β-galactoside transport in bacterial membrane preparations. |
| Biochem/physiol Actions: | Lactate dehydrogenase (LDH) plays an important role in the anaerobic metabolic pathway. The mammalian lactate dehydrogenase D (LDHD) is responsible for catalyzing the conversion of D-lactate to pyruvate. D-lactate dehydrogenase (D-LDH) is commonly employed in clinical settings for the detection of alanine aminotransferase (ALT) activity. Mutations in LDHD found in patients with D-lactic acidosis result in reduced LDHD activity. |
| General description: | Research Area: Cell Signaling Lactate dehydrogenase (LDH), a cytoplasmic enzyme, belongs to the class of oxidoreductases. It is found in almost all tissues particularly high concentrations in muscle, liver, and kidney. Moderate concentrations of this enzyme are also present in red blood cells. LDH is comprised of five isomeric forms that come together in tetramers made up of either muscle (M) or heart (H) subunits. D-Lactic Dehydrogenase (LDHD) codes for D-isomer and is highly expressed in tissues characterized by high metabolic rates and abundant mitochondria. |
| Other Notes: | One unit will reduce 1.0 μmole of pyruvate to |
| Packaging: | 25000 units in poly bottle |
| Physical form: | Lyophilized powder containing primarily dextran |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥80 units/mg solid |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 1.1.1.28 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |