Leupeptin hydrochloride
SIGMA/L9783 - microbial, ≥90% (HPLC)
Synonym: Acetyl-
CAS Number: 24125-16-4
Empirical Formula (Hill Notation): C20H38N6O4 · HCl
Molecular Weight: 463.01
MDL Number: MFCD00133457
Linear Formula: C20H38N6O4 · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: L9783-25MG
| assay | ≥90% (HPLC) |
| biological source | microbial |
| form | powder |
| InChI | 1S/C20H38N6O4.ClH/c1-12(2 |
| InChI key | OQQYPQNFLLAILR-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | Cl.CC(C)CC(NC(C)=O)C(=O)N |
| solubility | water: 50 mg/mL, clear, colorless |
| storage temp. | −20°C |
| Analysis Note: | Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin. |
| Biochem/physiol Actions: | Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. |
| Biochem/physiol Actions: | Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.) |
| Packaging: | 5, 25, 100 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |