Synonym: Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate; L-655708
CAS Number: 130477-52-0
Empirical Formula (Hill Notation): C18H19N3O4
Molecular Weight: 341.36
MDL Number: MFCD02684528
Linear Formula: C18H19N3O4
Product Type: Chemical
| assay |
≥98% (HPLC) |
| form |
powder |
| InChI |
1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1 |
| InChI key |
YKYOQIXTECBVBB-AWEZNQCLSA-N |
| originator |
Merck & Co., Inc., Kenilworth, NJ, U.S. |
| Quality Level |
100  |
| SMILES string |
CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12 |
| solubility |
DMSO: ≥6.0 mg/mL (Warmed) |
| |
H2O: insoluble |
| Application: |
L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner. |
| Biochem/physiol Actions: |
L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats. |
| Biochem/physiol Actions: |
Ligand for benzodiazepine site of GABAA receptors containing α5 subunits. |
| Biochem/physiol Actions: |
Novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α5 subunit. |
| Features and Benefits: |
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: |
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: |
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| UNSPSC |
12352200 |
