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LP44

SIGMA/L9793 - ≥98% (HPLC), solid

Synonym: 4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphth alenyl)-1-piperazinehexanamide hydrochloride

CAS Number: 824958-12-5
Empirical Formula (Hill Notation): C27H38ClN3OS
Molecular Weight: 488.13
MDL Number: MFCD09971090
Linear Formula: C27H38ClN3OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L9793-10MG 10 mg
 $218.00
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assay ≥98% (HPLC)
form solid
InChI 1S/C27H37N3OS.ClH/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24;/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31);1H
InChI key DWGKCWWWKHCVDH-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.CSc1ccccc1N2CCN(CCCCCC(=O)NC3CCCc4ccccc34)CC2
solubility DMSO: >10 mg/mL
  H2O: ≥2 mg/mL
storage temp. 2-8°C
Application: LP44 has been used as a 5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) agonist to study its effects on mitochondria-mediated leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome activation.
Biochem/physiol Actions: LP44 is a high affinity 5-HT7 receptor agonist.
Biochem/physiol Actions: LP44 is a high affinity 5-HT7 receptor agonist. Ki = 0.22 nM. LP44 displays selectivity over 5-HT1A and 5-HT2A receptors (200- and >1000-fold, respectively). LP44 induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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