LY-294,002 hydrochloride
SIGMA/L9908 - solid, ≥98% (HPLC)
Synonym: 2-
CAS Number: 934389-88-5
Empirical Formula (Hill Notation): C19H17NO3 · HCl
Molecular Weight: 343.80
MDL Number: MFCD00270881
Linear Formula: C19H17NO3 · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: L9908-1MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: L9908-5MG
| assay | ≥98% (HPLC) |
| biological source | microbial (Staphylococcus roseus) |
| color | white to off-white |
| form | solid |
| InChI | 1S/C19H17NO3/c21-17-13-18 |
| InChI key | CZQHHVNHHHRRDU-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O=C1C=C(Oc2c1cccc2-c3cccc |
| solubility | DMSO: >5 mg/mL |
| H2O: insoluble | |
| storage temp. | 2-8°C |
| Application: | LY-294,002 hydrochloride has been used in the inhibition of: • phosphoinositide 3-kinase (PI3K) in human lung cancer cell line • autophagy in mesenchymal stem cells (MSCs). • serine/threonine-specif |
| Biochem/physiol Actions: | Specific cell permeable phosphatidylinositol 3-kinase inhibitor. |
| Features and Benefits: | This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility. |
| Packaging: | 1, 5 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352207 |