Methylglyoxal solution
SIGMA/M0252 - ~40% in H2O
Synonym: Acetylformaldehyde; Pyruvaldehyde; Pyruvic aldehyde
CAS Number: 78-98-8
Empirical Formula (Hill Notation): C3H4O2
Molecular Weight: 72.06
MDL Number: MFCD00006960
Linear Formula: CH3COCHO
Product Type: Chemical
| concentration | ~40% (enzymatic) |
| ~40% in H2O | |
| density | 1.17 g/mL at 25 °C (lit.) |
| form | liquid |
| InChI | 1S/C3H4O2/c1-3(5)2-4/h2H, |
| InChI key | AIJULSRZWUXGPQ-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | [H]C(=O)C(C)=O |
| storage temp. | 2-8°C |
| Application: | Methylglyoxal solution has been used: • to assess glyoxalase 1 (GLO1) enzymatic activity • as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro • to regulate anxiety like behavior in mice • to induce peritoneal fibrosis in rats • to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts • for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway |
| General description: | Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing. |
| Symbol |    GHS05,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H290 - H317 - H318 - H341 |
| Precautionary statements | P202 - P234 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Density | 1.17 g/mL at 25 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352204 |