MRS 2578

SIGMA/M0319 - ≥95% (HPLC)

Synonym: 1,4-Di[3-(3-isothiocyanatophenyl)thioureido]butane

CAS Number: 711019-86-2
Empirical Formula (Hill Notation): C₂₀H₂₀N₆S₄
Molecular Weight: 472.67
MDL Number: MFCD07370141
Linear Formula: C₂₀H₂₀N₆S₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M0319-5MG	5 mg	$165.00 1/EA		Add To Favorites
45-M0319-25MG	25 mg	$630.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white
form	powder
InChI	1S/C20H20N6S4/c27-13-23-15-5-3-7-17(11-15)25-19(29)21-9-1-2-10-22-20(30)26-18-8-4-6-16(12-18)24-14-28/h3-8,11-12H,1-2,9-10H2,(H2,21,25,29)(H2,22,26,30)
InChI key	QOHNRGHTJPFMSL-UHFFFAOYSA-N
Quality Level	100
SMILES string	S=C=Nc1cccc(NC(=S)NCCCCNC(=S)Nc2cccc(c2)N=C=S)c1
solubility	DMSO: >5 mg/mL
	H₂O: insoluble
storage condition	desiccated
storage temp.	2-8°C

Application:	MRS 2578 has been used an antagonist of purinoceptor P2Y6: • to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine • in P. aeruginosa infected mice to test its effect on the inflammatory responses • to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes
Biochem/physiol Actions:	MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.
Biochem/physiol Actions:	Potent and irreversible antagonist of P2Y₆nucleotide receptor.
Features and Benefits:	This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 - H312 + H332 - H315 - H319 - H334 - H335
Precautionary statements	P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38-42
Safety Statements	22-26-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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