Melanin
SIGMA/M0418 - Synthetic, BioReagent, suitable for cell culture
CAS Number: 8049-97-6
EC Number: 232-473-6
MDL Number: MFCD00131581
Product Type: Chemical
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| assay | ≥85% (TLC) |
| biological source | synthetic |
| form | powder |
| InChI | 1S/C18H10N2O4/c1-5-13-9-7 |
| InChI key | XUMBMVFBXHLACL-UHFFFAOYSA |
| product line | BioReagent |
| SMILES string | [nH]1c2c3c(c4c5c([nH]c4)c |
| solubility | 1 N NH4OH: 20 mg/mL |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| Application: | Melanin has been used: • to incubate normal human keratinocytes for Masson-Fontana staining • as a standard in the determination of melanin content in normal human epidermal melanocytes and immortalized human keratinocytes • as an absorber to mimic human skin or melanocytic nevi and melanoma |
| Biochem/physiol Actions: | Melanin plays a role in camouflage and energy harvesting. It also helps in protection against ionizing UV radiations, protection against biotic factors such as host defense against pathogens, and abiotic factors like heat, cold and osmotic stress. Melanin acts as a potent cation chelator and is a component of several photoprotective creams as it facilitates free radical scavenging activity. Melanin may be useful as a photo protectant in cell culture. |
| General description: | Melanin is a distinctive class of pigment found in animals, plants, bacteria, and fungi. It is an amorphous polymer formed by the polymerization of phenolic and indolic compounds. |
| Preparation Note: | Prepared by oxidation of tyrosine with hydrogen peroxide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥85% (TLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352209 |