Mitomycin C from Streptomyces caespitosus

SIGMA/M0503 - powder, contains NaCl as solubilizer

CAS Number: 50-07-7
Empirical Formula (Hill Notation): C₁₅H₁₈N₄O₅
Molecular Weight: 334.33
MDL Number: MFCD00078109
Linear Formula: C₁₅H₁₈N₄O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M0503-2MG	2 mg	$163.00 1/EA		Add To Favorites
45-M0503-5X2MG	2 mg	$645.00 5/EA		Add To Favorites
45-M0503-10X2MG	2 mg	$1090.00 10/EA		Add To Favorites
45-M0503-50X2MG	2 mg	$4160.00 50/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

	(1) 3.2, (2) 6.5
antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
biological source	Streptomyces caespitosus
color	gray
	purple/blue
contains	NaCl as solubilizer
form	powder
InChI	1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI key	NWIBSHFKIJFRCO-WUDYKRTCSA-N
mode of action	DNA synthesis \| interferes
Quality Level	200
SMILES string	[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O
solubility	H₂O: 1 vial + 4 mL, clear to slightly hazy, blue to purple
storage temp.	2-8°C

Application:	Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.
Biochem/physiol Actions:	Mode of Action: This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5′-CpG-3′. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication. Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.
Disclaimer:	This vial contains 2 mg Mitomycin C and 48 mg NaCl. Stock solutions should be filter sterilized and stored at 2-8°C in the dark. Solutions at pH 6-9 can be stored at 0-5°C for up to a week, but if a precipitate forms, a fresh solution should be prepared - the precipitated solution has been proven toxic to cells.
General description:	Chemical structure: aziridine
Preparation Note:	Mitomycin C is soluble in water at .5 mg/mL, with a pH of 6.0-7.5. It undergoes rapid degradation in acidic solutions with pH<6, and is mostly likely to retain activity in solutions with a pH between 6-9.

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H302 - H351
Precautionary statements	P201 - P301 + P312 + P330 - P308 + P313
Hazard Codes	Xn
Risk Statements	22-40
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352207

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