Microsomes from Liver, Pooled
SIGMA/M0567 - from human male
Synonym: lab equipment accessory
Product Type: Chemical
| biological source | human male |
| form | liquid |
| packaging | vial of ~10 mg |
| Quality Level | 200  |
| shipped in | dry ice |
| storage temp. | −70°C |
| Application: | Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes. |
| Application: | Microsomes from Liver, Pooled has been used: • in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process • as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS) • to study the metabolization of enantiomeric peptide D3 |
| Biochem/physiol Actions: | Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions. |
| Biochem/physiol Actions: | N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes. |
| Biochem/physiol Actions: | Source of drug metabolizing enzymes, including cytochrome P-450. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −70°C |
| UNSPSC | 12352204 |