Myelin Basic Protein Antigen from human brain
SIGMA/M0689 - ≥95% (SDS-PAGE)
Synonym: Myelin Antigen; Myelin Basic Protein
MDL Number: MFCD03457654
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | ≥95% (SDS-PAGE) |
| biological source | human brain |
| form | lyophilized powder |
| Quality Level | 200  |
| storage temp. | −20°C |
| technique(s) | ELISA: suitable |
| UniProt accession no. | P02686  |
| Application: | Myelin basic protein antigen from human brain has been used in enzyme-linked immunosorbent spot assays. |
| Biochem/physiol Actions: | Determined using polyclonal and monoclonal antibodies against MBP. |
| Biochem/physiol Actions: | Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). It also has a crucial role to play in human demyelinating diseases including multiple sclerosis (MS). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. |
| General description: | Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of myelin sheath and is highly expressed in central nervous system (CNS). |
| Other Notes: | Blood samples from donors were tested and found to be negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV. |
| Physical form: | Lyophilized from 10mM HCl. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |