(+)-MK-801 hydrogen maleate

SIGMA/M107 - powder

Synonym: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate; Dizocilpine hydrogen maleate

CAS Number: 77086-22-7
Empirical Formula (Hill Notation): C₁₆H₁₅N · C₄H₄O₄
Molecular Weight: 337.37
EC Number: 278-614-5
MDL Number: MFCD00082465
Linear Formula: C₁₆H₁₅N · C₄H₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M107-5MG	5 mg	$130.00 1/EA	Add To Favorites
45-M107-25MG	25 mg	$267.00 1/EA	Add To Favorites
45-M107-50MG	50 mg	$450.00 1/EA	Add To Favorites
45-M107-250MG	250 mg	$1920.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M107-250MG

Properties
Descriptions
Safety Info.
Basic Data

color	white
form	powder
InChI	1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1
InChI key	QLTXKCWMEZIHBJ-PJGJYSAQSA-N
optical activity	[α]25/D +117°, c = 1 in methanol(lit.)
Quality Level	100
SMILES string	[H]C(=C(/[H])C(O)=O)C(O)=O.C[C@]12N[C@H](Cc3ccccc13)c4ccccc24
solubility	0.1 M HCl: soluble
	DMSO: >20 mg/mL
	ethanol: soluble
	H₂O: 6 mg/mL

Application:	(+)-MK-801 hydrogen maleate has been used in following experimental studies: It is injected to mice to study the effect of systemic administration of CIQ [(3-chlorophenyl) (6, 7-dimethoxy-1-((4-methoxyphenoxy) methyl)-3, 4-dihydroisoquinolin-2(1H)-yl)methanone] on schizophrenia-like behaviours stimulated by MK-801. It has been used to block the NMDA (N-methyl-D-aspartate) receptor-mediated rtPA (recombinant tissue plasminogen activator)-enhanced excitotoxic pathway. It is injected in varied doses to study behavioral performance altering effects of MK-801 in zebrafish (Danio rerio). It is used as a NMDA receptor antagonist to study 3-OH-GA-induced neuronal damage via NMDA receptors.
Biochem/physiol Actions:	Experimental study shows that MK-801, influence circling behavior in a direction-specific manner, modify swimming activity and place preference in zebrafish. Acute injection of MK-801, dose dependently, enhances extracellular acetylcholine (ACh) release in the rat parietal cortex. For intracerebral hematomas, MK-801 might act as a potent supplement to reduce delayed edema after recombinant tissue plasminogen activator (rtPA) clot lysis. MK-801 functions as an antidepressant in the social defeat stress model, but it doesn’t have long-lasting effect.
Biochem/physiol Actions:	Highly potent and selective non-competitive NMDA glutamate receptor antagonist that acts at the NMDA receptor-operated ion channel as an open channel blocker. Inhibits behavioral sensitization to psychostimulants and ethanol.
General description:	(+)-MK-801 hydrogen maleate is a highly potent and selective non-competitive NMDA glutamate receptor antagonist that acts at the NMDA receptor-operated ion channel as an open channel blocker. Neurons are depolarized when MK-801 binds to the Glu (40 Glu) receptor (NMDA receptor- ion channel complex) at two sites. 40 Glu is the brain′s primary excitatory neurotransmitter. MK-801 attaches to the ion channel at the binding site PCP of the receptor. Receptor blockade occurs in a voltage-dependent manner. It also known as dizocilpine hydrogen maleate is an effective anticonvulsant with both anxiolytic and sympathomimetic properties.(+)-MK-801 hydrogen maleate stimulates locomotion in monoamine-depleted mice.
Packaging:	25 mg in poly bottle
Packaging:	5 mg in glass bottle
Packaging:	50, 250 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

12352209

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