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Midostaurin hydrate

SIGMA/M1323 - ≥98% (HPLC), solid

Synonym: CGP 41251; N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide; N-benzoylstaurosporine; PKC-412

CAS Number: 1217450-80-0
Empirical Formula (Hill Notation): C35H30N4O4 · xH2O
Molecular Weight: 570.64 (anhydrous basis)
MDL Number: MFCD12828879
Linear Formula: C35H30N4O4 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M1323-1MG 1 mg
 $119.00
1/EA		 Add To Favorites
45-M1323-5MG 5 mg
 $439.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts M1323-5MG.

 

assay ≥98% (HPLC)
color off-white
form solid
InChI 1S/C35H30N4O4.H2O/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38;/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40);1H2/t25-,26-,32-,35+;/m1./s1
InChI key YEKDLUZCCDJYAJ-LJAYRLSQSA-N
Quality Level 100 
SMILES string O.CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)[n@@H]3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8[n@H]2c7c35)N(C)C(=O)c9ccccc9
solubility DMSO: >10 mg/mL
storage temp. −20°C
Biochem/physiol Actions: Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF.
Biochem/physiol Actions: Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF. Midostaurin inhibits cell growth and phosphorylation of FLT3, STAT5, and ERK. Midostaurin is a potent inhibitor of a spectrum of FLT3 activation loop mutations.
Features and Benefits: This compound is featured on the PKC  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 1, 5 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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