Synonym: CGP 41251; N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide; N-benzoylstaurosporine; PKC-412
CAS Number: 1217450-80-0
Empirical Formula (Hill Notation): C35H30N4O4 · xH2O
Molecular Weight: 570.64 (anhydrous basis)
MDL Number: MFCD12828879
Linear Formula: C35H30N4O4 · xH2O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
off-white |
| form |
solid |
| InChI |
1S/C35H30N4O4.H2O/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38;/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40);1H2/t25-,26-,32-,35+;/m1./s1 |
| InChI key |
YEKDLUZCCDJYAJ-LJAYRLSQSA-N |
| Quality Level |
100  |
| SMILES string |
O.CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)[n@@H]3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8[n@H]2c7c35)N(C)C(=O)c9ccccc9 |
| solubility |
DMSO: >10 mg/mL |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF. |
| Biochem/physiol Actions: |
Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF. Midostaurin inhibits cell growth and phosphorylation of FLT3, STAT5, and ERK. Midostaurin is a potent inhibitor of a spectrum of FLT3 activation loop mutations. |
| Features and Benefits: |
This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
1, 5 mg in glass bottle |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
GHS08