Methysergide maleate salt

SIGMA/M137 - solid

CAS Number: 129-49-7
Empirical Formula (Hill Notation): C₂₁H₂₇N₃O₂ · C₄H₄O₄
Molecular Weight: 469.53
EC Number: 204-950-9
MDL Number: MFCD00083185
Linear Formula: C₂₁H₂₇N₃O₂ · C₄H₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M137-2MG	2 mg	$167.00 1/EA		Add To Favorites
45-M137-10MG	10 mg	$357.00 1/EA		Add To Favorites
45-M137-50MG	50 mg	$1160.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

color	white to off-white
form	solid
InChI	1S/C21H27N3O2.C4H4O4/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14;5-3(6)1-2-4(7)8/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15+,19-;/m1./s1
InChI key	LWYXFDXUMVEZKS-ZVFOLQIPSA-N
originator	Novartis
Quality Level	100
SMILES string	OC(=O)C=C/C(O)=O.[H][C@@]12Cc3cn(C)c4cccc(C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO)c34
solubility	DMSO: >10 mg/mL
	H₂O: 2 mg/mL

Application:	Methysergide maleate salt has been used as a serotonin (5HT) receptor antagonist to evaluate the potential systemic effects of methysergide (METH) and 5-HT infusions on production and milk composition in multiparous Holstein cows. It may also be used as a serotonin receptor blocker to identify the serotonergic receptor type involved in the direct excitation of mitral cells in the main olfactory bulb.
Biochem/physiol Actions:	Methysergide maleate, also known as sansert, is a semisynthetic ergot alkaloid ergometrine derivative. Methysergide is a serotonin 1(5-HT1) receptor agonist and a nonselective 5-HT2 and 5-HT7 serotonin receptor antagonist. Methysergide maleate is used as a pharmacological agent to treat migraines and other vascular headaches. But, prolonged and uncontrolled use of this drug may cause Leriche′s syndrome, angina pectoris, acute ischemia of the limbs. In addition, gastrointestinal side effects, such as abdominal cramps, nausea, and diarrhea have also been observed in few patients.
Features and Benefits:	This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

12352200

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