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4-Methylpyrazole hydrochloride

SIGMA/M1387 - alcohol dehydrogenase inhibitor

Synonym: Fomepizole

CAS Number: 56010-88-9
Empirical Formula (Hill Notation): C4H6N2 · HCl
Molecular Weight: 118.56
MDL Number: MFCD00012707
Linear Formula: C4H6N2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M1387-100MG 100 mg
 $161.00
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45-M1387-500MG 500 mg
 $556.00
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45-M1387-1G 1 g
 $948.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M1387-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M1387-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M1387-500MG

 

assay ≥95%
biological source synthetic (organic)
form powder
InChI 1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H
InChI key PUCXJHNDMYZOHG-UHFFFAOYSA-N
mp 157-159  °C
Quality Level 200 
SMILES string Cl.Cc1cn[nH]c1
solubility methanol: 100 mg/mL, clear, colorless to yellow
storage temp. 2-8°C
Application: 4-Methylpyrazole hydrochloride has been used:
• as a cytochrome P450 2E1 inhibitor
• as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
• to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells
Application: Useful as an antidote in methanol and ethylene glycol poisoning.
Biochem/physiol Actions: 4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.
Biochem/physiol Actions: Alcohol dehydrogenase inhibitor
Packaging: 1 g in poly bottle
Packaging: 100, 500 mg in poly bottle
Purity ≥95%
mp 157-159  °C
Storage Temp. 2-8°C
UNSPSC 12352202

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