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Methyllycaconitine citrate salt

SIGMA/M168 - from Delphinium brownii seeds, ≥96% (HPLC)

Synonym: MLA; [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate salt

CAS Number: 112825-05-5
Empirical Formula (Hill Notation): C37H50N2O10 · xC6H8O7
Molecular Weight: 682.80 (salt-free basis)
MDL Number: MFCD00153837
Linear Formula: C37H50N2O10 · xC6H8O7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M168-5MG 5 mg
 $125.00
1/EA		 Add To Favorites
45-M168-25MG 25 mg
 $445.00
1/EA		 Add To Favorites

 

assay ≥96% (HPLC)
biological source Delphinium brownii seeds
color white
InChI 1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33?,34-,35+,36-,37+;/m0./s1
InChI key INBLZNJHDLEWPS-DDIMIZGISA-N
Quality Level 100 
SMILES string O=C(OC[C@]12[C@@]([C@]3([C@H](CC1)OC)[C@@H]4N(C2)CC)([H])[C@@H]([C@]4(O)[C@]5(O)[C@]6([H])[C@@]3([H])C[C@@]([C@H](C5)OC)([H])[C@@H]6OC)OC)C7=CC=CC=C7N8C([C@@H](C)CC8=O)=O.OC(CC(CC(O)=O)(C(O)=O)O)=O
solubility H2O: 42 mg/mL
storage temp. −20°C
Application: Methyllycaconitine citrate salt has been used as an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist:
• to study its effects on inflammatory response in rats post nicotine treatment
• to block the activity of galantamine
• to study its effects on the hepatic branch of the vagus nerve (hVNS) in rats
Biochem/physiol Actions: Methyllycaconitine (MLA) is an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist. It is a norditerpenoid alkaloid synthesized by several species of Delphinium. MLA binds to the binding site of neuronal α-bungarotoxin. Low doses of MLA are associated with improvement of cognition in animals.
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Nicotinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥96% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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