Methylmalonyl coenzyme A tetralithium salt hydrate

SIGMA/M1762 - ≥90% (HPLC)

Synonym: α-Methylmalonyl coenzyme A tetralithium salt; MM-CoA

CAS Number: 104809-02-1
Empirical Formula (Hill Notation): C₂₅H₃₆Li₄N₇O₁₉P₃S · xH₂O
Molecular Weight: 891.34 (anhydrous basis)
MDL Number: MFCD10567443
Linear Formula: C₂₅H₃₆Li₄N₇O₁₉P₃S · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M1762-1MG	1 mg	$163.00 1/EA	Add To Favorites
45-M1762-5MG	5 mg	$525.00 1/EA	Add To Favorites
45-M1762-25MG	25 mg	$2100.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M1762-25MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
form	powder
InChI	1S/C25H40N7O19P3S.4Li.H2O/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32;;;;;/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42);;;;;1H2/q;4*+1;/p-4/t12?,13-,16-,17-,18+,22-;;;;;/m1...../s1
InChI key	ANDKBBZIPFWODN-WLVKLPLXSA-J
Quality Level	200
SMILES string	[Li+].[Li+].[Li+].[Li+].O.CC(C([O-])=O)C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23
solubility	H₂O: soluble-50 mg/mL, clear, colorless
storage temp.	−20°C

Application:	Coenzyme A functions as an acyl group carrier, acetyl-CoA. Methylmalonyl coenzyme A (MM-CoA) is a substrate used to study the specificity and kinetics of enzymes such as methylmalonyl Coenzyme A mutase (succinyl-Ca forming), methylmalonyl-CoA decarboxylase (EC 4.1.1.41), and methylmalonyl-CoA hydrolase (EC 3.1.2.17).
Application:	Methylmalonyl coenzyme A (CoA) has been used in the preparation of the calibration curve in ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). It has also been used in the measurement of methylmalonyl-CoA mutase and methylmalonyl-CoA epimerase activity.
Biochem/physiol Actions:	Methylmalonyl coenzyme A (CoA) is a catabolite of odd-chain fatty acids, cholesterol and few amino acids like valine, isoleucine, methionine, threonine. It is produced by the activity of the enzyme propionyl-CoA carboxylase(PCC). Methylmalonyl coenzyme A (CoA) is converted to succinyl-CoA by the methylmalonyl-CoA mutase (MCM) and vitamin B12 as the cofactor. Either a low MCM activity or an altered metabolism of vitamin B12 causes the inherited metabolic disease methylmalonic acidemia (MMA).
Packaging:	1, 5 mg in glass bottle
Packaging:	25 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	22-26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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