S-methyl-5′-thioadenosine phosphorylase human
SIGMA/M1949
Product Type: Chemical
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| assay | ≥80% (SDS-PAGE) |
| form | solution |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| relevant disease(s) | cancer |
| shipped in | dry ice |
| storage temp. | −70°C |
| Application: | S-methyl-5′-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors . MTAP may be a used to develop potential therapeutic strategies for hepatocellular carcinoma (HCC) since MTAP inactivation has been linked to HCC development and invasiveness . |
| Biochem/physiol Actions: | MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation . |
| General description: | N-terminal GST-tagged 57 kDa protein containing amino acids 2-end. |
| Legal Information: | TWEEN is a registered trademark of Croda International PLC |
| Physical form: | Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween®-20, 10% glycerol,and 3 mM DTT. |
| Purity | ≥80% (SDS-PAGE) |
| Storage Temp. | −70°C |
| Enzyme Commission (EC) Number | 2.4.2.28 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |