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Melphalan

SIGMA/M2011 - powder

Synonym: 4-[Bis(2-chloroethyl)amino]-L-phenylalanine; L-PAM; L-Phenylalanine mustard

CAS Number: 148-82-3
Empirical Formula (Hill Notation): C13H18Cl2N2O2
Molecular Weight: 305.20
EC Number: 205-726-3
MDL Number: MFCD00057717
Linear Formula: C13H18Cl2N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M2011-100MG 100 mg
 $239.00
1/EA		 Add To Favorites
45-M2011-1G 1 g
 $1200.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M2011-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M2011-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M2011-250MG

 

color white
form powder
InChI 1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
InChI key SGDBTWWWUNNDEQ-LBPRGKRZSA-N
Quality Level 200 
SMILES string N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(O)=O
Application: Melphalan has been used as a drug along with HDAC-inhibitor JNJ-26481585 to treat multiple myeloma (MM) in cell lines and as a chemotherapeutic agent for breast cancer cell line.
Biochem/physiol Actions: In rat, melphalan in isolated lung perfusion (ILP) functions as a potent therapeutics for sarcomatous pulmonary metastases. It forms DNA intrastrand crosslinks by bifunctional alkylation in 5′-GGC sequences. Melphalan acts as a bone-marrow depressant and is implicated in the treatment of multiple myeloma and ovarian cancer.
Biochem/physiol Actions: Melphalan is an antineoplastic agent.
General description: Melphalan also known as L-phenylalanine mustard is an alkylating agent. It belongs to the class of nitrogen mustards, which act as chemotherapeutic agents.
Packaging: 1 g in glass bottle
Packaging: 100, 250 mg in glass bottle
UNSPSC 12352207

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