Merbarone

SIGMA/M2070 - ≥98% (HPLC), solid

Synonym: 5-(N-Phenylcarbamoyl)-2-thiobarbituric acid; NSC-336628

CAS Number: 97534-21-9
Empirical Formula (Hill Notation): C₁₁H₉N₃O₃S
Molecular Weight: 263.27
MDL Number: MFCD00866337
Linear Formula: C₁₁H₉N₃O₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M2070-25MG	25 mg	$178.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
drug control	regulated under CDSA - not available from Sigma-Aldrich Canada
form	solid
InChI	1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
InChI key	JARCFMKMOFFIGZ-UHFFFAOYSA-N
Quality Level	200
SMILES string	O=C1NC(=S)NC(=O)C1C(=O)Nc2ccccc2
solubility	DMSO: >5 mg/mL
storage temp.	2-8°C

Application:	Merbarone has been used to study its effect on the occurrence of DNA lesions.
Biochem/physiol Actions:	Selective topoisomerase II inhibitor. Blocks topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. Induces apoptosis in CEM cells via caspase 3 dependent mechanism.
Biochem/physiol Actions:	Thiobarbituric acid with aniline joined by an amide linkage forms merbarone. It is known to prolong cell cycle progression by inducing DNA double strand breaks, retarding S phase and arresting G2 phase. This delays cell entry into mitosis. Merbarone possesses cytotoxic and genotoxic action and promotes endoreduplication. Merbarone has mild antitumor action and is also found to nephrotoxic.
Packaging:	25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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