Myelin Basic Protein from guinea pig brain
SIGMA/M2295 - ≥80% (SDS-PAGE), lyophilized powder, from guinea pig brain
Synonym: MBP
MDL Number: MFCD00131640
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| application(s) | cell analysis |
| assay | ≥80% (SDS-PAGE) |
| biological source | guinea pig brain |
| form | lyophilized powder |
| Quality Level | 200  |
| storage temp. | −20°C |
| technique(s) | cell based assay: suitable |
| UniProt accession no. | P25188  |
| Analysis Note: | May contain traces of urea-glycine buffer salts. |
| Application: | Myelin Basic Protein fromguinea pig brain has been used as a kinase substrate: to analyse in vitrokinase activity, in protein phosphorylation analysis, in ATG1 kinaseassay |
| Biochem/physiol Actions: | Major structural protein of CNS myelin. Used to induce experimental allergic encephalomyelitis. |
| Biochem/physiol Actions: | Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis. |
| Biochem/physiol Actions: | Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme. |
| Biochem/physiol Actions: | Used as a kinase substrate. |
| General description: | Myelin Basic Protein (MBP) expressed in guinea pig brain contains 167 amino acids and has a molecular weight of 18,256Da. |
| General description: | Research area: Cell SignallingMyelin basic protein (MBP) is an important constituent of the myelin sheath of CNS (central nervous system). It is an auto-immunogen. |
| Packaging: | 1, 5 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥80% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |