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Mefloquine hydrochloride

SIGMA/M2319 - ≥98% (HPLC), powder

Synonym: (AS)-rel-a-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride

CAS Number: 51773-92-3
Empirical Formula (Hill Notation): C17H17ClF6N2O
Molecular Weight: 414.77
EC Number: 257-412-0
MDL Number: MFCD00797519
Linear Formula: C17H17ClF6N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M2319-100MG 100 mg
 $191.00
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assay ≥98% (HPLC)
color white
form powder
InChI 1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1
InChI key WESWYMRNZNDGBX-YLCXCWDSSA-N
Quality Level 100 
SMILES string Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F
solubility DMSO: soluble 38 mg/mL
  H2O: insoluble
storage condition desiccated
Application: Mefloquine hydrochloride has been used:
• to treat cochlear organotypic cultures with various doses to evaluate its role in cellular pathway involved in apoptosis
• in screening for in vitro antischistosomal activity
• in cytotoxicity assay of glioblastoma cells
Biochem/physiol Actions: Blocker of gap junction channels Cx36 and Cx50.
Biochem/physiol Actions: Mefloquine is broadly used as an antimalarial drug. It inhibits 80S ribosomes of Plasmodium. It has numerous side effects like anxiety, dizziness, tremor, headache, and hearing loss. Mefloquine damages cochlear and vestibular hair cells through apoptosis. It also damages spiral ganglion neurons, degenerates cortical neuron and disrupts neuronal calcium homeostasis.
Packaging: 100 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352202

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