α-(Methylamino)isobutyric acid
SIGMA/M2383 - ≥97% (titration)
Synonym: 2,N-Dimethylalanine; 2-
CAS Number: 2566-34-9
Empirical Formula (Hill Notation): C5H11NO2
Molecular Weight: 117.15
EC Number: 219-898-2
MDL Number: MFCD00004191
Linear Formula: CH3NHC(CH3)2COOH
Product Type: Chemical
| assay | ≥97% (titration) |
| color | white |
| form | powder |
| InChI | 1S/C5H11NO2/c1-5(2,6-3)4( |
| InChI key | DLAMVQGYEVKIRE-UHFFFAOYSA |
| mp | >300 °C (lit.) |
| Quality Level | 100  |
| SMILES string | CNC(C)(C)C(O)=O |
| storage temp. | −20°C |
| technique(s) | ligand binding assay: suitable |
| Application: | α-(Methylamino)isobutyric acid (MeAIB) has been used: • as a system A transport system inhibitor to perform inhibition experiments • as a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slices • as an N-acetyltransferase (SNAT) inhibitor in Hank′s balanced salt solution (HBSS) to study its influence on the uptake of 14C-cysteine/ radioactive-labeled cysteine |
| Biochem/physiol Actions: | α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway. |
| Packaging: | 1 g in poly bottle |
| Packaging: | 250 mg in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (titration) |
| mp | >300 °C (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 12352209 |