N6-Methyl-2′-deoxyadenosine
SIGMA/M2389
Synonym: 6mdA; N6-Me-dAdo; m6dA
CAS Number: 2002-35-9
Empirical Formula (Hill Notation): C11H15N5O3
Molecular Weight: 265.27
MDL Number: MFCD00055999
Linear Formula: C11H15N5O3
Product Type: Chemical
| assay | ≥98% (TLC) |
| form | powder |
| InChI | 1S/C11H15N5O3/c1-12-10-9- |
| InChI key | DYSDOYRQWBDGQQ-XLPZGREQSA |
| Quality Level | 200  |
| SMILES string | CNc1ncnc2n(cnc12)[C@H]3C[ |
| solubility | acetic acid: 49.00-51.00 mg/mL, clear, colorless |
| storage temp. | −20°C |
| Application: | N6-Methyl-2′-deoxyadenosine has been used as a standard to assess the levels of modified bases in genomic DNA by the ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-QQQ-MS/MS) method. It has also been used to study its potential in promoting the proliferation oferythroid progenitor cells. |
| Biochem/physiol Actions: | N6-Methyl-2′-deoxyadenosine (N6-Me-dAdo) is a precursor of N6-methyl 2′-deoxyadenosine 3′,5′-bisphosphate (N6MABP), a competitive and selective inhibitor of P2Y1 receptors. It is located at the transcription start site and plays a role in increased gene expression in Chlamydomonas reindardtii. N6-Me-dAdo augments the within transposable elements and is present at higher levels during the development of Drosophila. It is involved in the regulation of gene transcription, DNA repair, and replication in prokaryotes and protists. N6-Me-dAdo complemented with gene bodies might induce gene expression in human cells. |
| Packaging: | 25 mg in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (TLC) |
| Storage Temp. | −20°C |
| UNSPSC | 41106305 |