MB-3
SIGMA/M2449 - ≥95% (HPLC)
Synonym: γ-butyrolactone; Butyrolactone 3; (2R,3S)
Empirical Formula (Hill Notation): C9H12O4
Molecular Weight: 184.19
MDL Number: MFCD08702690
Linear Formula: C9H12O4
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C9H12O4/c1-3-4-6-7(8(1 |
| InChI key | SRQUTZJZABSZRQ-RQJHMYQMSA |
| Quality Level | 100  |
| SMILES string | CCC[C@H]1OC(=O)C(=C)[C@@H |
| solubility | DMSO: ≥20 mg/mL |
| H2O: ≥10 mg/mL | |
| storage temp. | −20°C |
| Application: | MB-3 has been used as a general control non-repressible 5 (GCN5) inhibitor: • to study its effects on lamin A/C-associated pY19-Cav-2-mediated histone H3 acetylations • to analyze its effects on the growth of Arabidopsis thaliana seedlings • to study its effects on craniofacial chondrocyte maturation |
| Biochem/physiol Actions: | MB-3 can modify the gene expression in murine embryonic stem cells as well as yeast. It hinders the acetyltransferase activity of general control non-repressible 5 (GCN5) by binding to acetyl CoA pocket present in GCN5. |
| Biochem/physiol Actions: | MB-3 is a Gcn5 HAT (Histone Acetyltransferase) inhibitor; anti-inflammatory, anti-carcinogenic. |
| Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |