Mianserin hydrochloride
SIGMA/M2525
Synonym: 1,2,3,4,10,14b-
CAS Number: 21535-47-7
Empirical Formula (Hill Notation): C18H20N2 · HCl
Molecular Weight: 300.83
EC Number: 244-426-7
MDL Number: MFCD00055072
Linear Formula: C18H20N2 · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M2525-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M2525-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M2525-250MG
| InChI | 1S/C18H20N2.ClH/c1-19-10- |
| InChI key | YNPFMWCWRVTGKJ-UHFFFAOYSA |
| originator | Organon |
| Quality Level | 200  |
| SMILES string | Cl.CN1CCN2C(C1)c3ccccc3Cc |
| solubility | ethanol: 5.6 mg/mL |
| H2O: 3.4 mg/mL | |
| storage temp. | 2-8°C |
| Application: | Mianserin hydrochloride has been used: • as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R) • as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor (BDNF) mRNA expression • as a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation |
| Biochem/physiol Actions: | Antidepressant; antagonist/inverse agonist at 5-HT2 serotonin receptors; also blocks the H1 histamine receptor and the α2 adrenoceptor. |
| Biochem/physiol Actions: | Mianserin is a tetracyclic compound with sedative property. It lacks anticholinergic activity and is not effective on serotoninergic mechanisms. Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products. |
| Features and Benefits: | This compound was developed by Organon . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 1 g in poly bottle |
| Packaging: | 100, 250 mg in poly bottle |
| Preparation Note: | Solutions may be stored for several days at 4°C. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |