Mevastatin

SIGMA/M2537 - ≥98% (HPLC), powder or crystals

Synonym: Compactin; ML-236B

CAS Number: 73573-88-3
Empirical Formula (Hill Notation): C₂₃H₃₄O₅
Molecular Weight: 390.51
MDL Number: MFCD05662341
Linear Formula: C₂₃H₃₄O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-M2537-5MG	5 mg	$167.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
assay	≥98% (HPLC)
color	white to light yellow
form	powder or crystals
InChI	1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
InChI key	AJLFOPYRIVGYMJ-INTXDZFKSA-N
mode of action	enzyme \| inhibits
mp	151 °C
originator	Daiichi-Sankyo
Quality Level	200
SMILES string	[H][C@]12[C@H](CCC=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)[C@@H](C)CC
solubility	ethanol: 25-26 mg/mL, clear, colorless
storage temp.	2-8°C

Application:	Mevastatin has been used: • to analyze its effects on chronic lymphocytic leukemia (CLL) cells by cytotoxic assay • as a prenylation inhibitor to analyze its effects on human embryonic kidney (HEK) cells transfected with K-Ras • as a statin agent to study its anti-cancer effect on human breast cancer cells and glioblastoma in vitro
Biochem/physiol Actions:	Mevastatin is a selective inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme(A) reductase (HMG-CoA reductase), a major enzyme involved in cholesterol synthesis. It acts as a cholesterol-lowering agent. Mevastatin is obtained from various species of fungi. It acts as an antiresorptive agent and has therapeutic effects to treat osteoporosis. Mevastatin inhibits bone resorption by triggering osteoclast apoptosis. It is also involved in the inhibition of prenylation of proteins such as Ras. Mevastatin increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels by blocking the geranylgeranylation of transcription factor Rho.
Features and Benefits:	This compound was developed by Daiichi-Sankyo . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Chemical structure: statin
General description:	Mevastatin is a polyketide that belongs to the class of statins. It contains a hydroxy-hexahydronaphthalene ring.
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
mp	151 °C
Storage Temp.	2-8°C
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.