Mexiletine hydrochloride
SIGMA/M2727 - powder
Synonym: 1-
CAS Number: 5370-01-4
Empirical Formula (Hill Notation): C11H17NO · HCl
Molecular Weight: 215.72
EC Number: 250-825-7
MDL Number: MFCD00216024
Linear Formula: C11H17NO · HCl
Product Type: Chemical
| assay | ≥98% (GC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C11H17NO.ClH/c1-8-5-4- |
| InChI key | NFEIBWMZVIVJLQ-UHFFFAOYSA |
| originator | Boehringer Ingelheim |
| Quality Level | 200  |
| SMILES string | Cl[H].CC(N)COc1c(C)cccc1C |
| solubility | methanol: 50 mg/mL |
| storage temp. | 2-8°C |
| Application: | Mexiletine hydrochloride has been used as a sodium channel blocker: • expressed in chinese hamster ovary cells • in human embryonic kidney (HEK) cells for whole cell patch-clamp studies • electrophysiology studies in HEK cells expressing Nav1.7 protein |
| Biochem/physiol Actions: | Mexiletine is a potent sodium channel blocker. It is a cardiac antiarrhythmic and is used as an adjuvant in headache and neuropathic pain Mexiletine is used for treating myotonia in sodium channelopathies and reduces the cardiac action potential depolarization but shows no impact on atrial refractoriness. Its inhibitory effect on sodium channels is effective in treating potassium aggravated myotonia. |
| Features and Benefits: | This compound was developed by Boehringer Ingelheim . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Mexiletine is a class I B antiarrhythmic and an analog of lidocaine. It has shelf life of 10-12 hours and is metabolized in liver and eliminated post reduction, oxidation deamination or conjugation. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (GC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |