Mizoribine

SIGMA/M3047 - ≥98% (TLC)

Synonym: N′-(β-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide

CAS Number: 50924-49-7
Empirical Formula (Hill Notation): C₉H₁₃N₃O₆
Molecular Weight: 259.22
MDL Number: MFCD00057221
Linear Formula: C₉H₁₃N₃O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M3047-10MG	10 mg	$174.00 1/EA	Add To Favorites
45-M3047-25MG	25 mg	$380.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M3047-25MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
InChI	1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1
InChI key	HZQDCMWJEBCWBR-UUOKFMHZSA-N
Quality Level	200
SMILES string	NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1O
storage temp.	2-8°C

Application:	Mizoribine has been used in topical treatment to evaluate its effect on ocular surface damage of dry eye in B6 mice subjected to desiccating stress (DS). It has also been used as an inosine monophosphate dehydrogenase (IMPDH) inhibitor to test its in vivo efficacy.
Biochem/physiol Actions:	Mizoribine is an imidazole nucleoside possessing strong immunosuppressive properties. It selectively blocks T-cell proliferation response to mitogenic and allo-antigenic stimulation. Mizoribine blocks the movement of T cells from G to S phase. In addition, it significantly decreases the number of B cells at the S, G, and M phases. Mizoribine inhibits de novo synthesis of nucleotides by inhibition of inosine monophosphate dehydrogenase. The resulting nucleotide depletion inhibits DNA synthesis.(3)
Packaging:	10 mg in poly bottle
Packaging:	25 mg in glass bottle

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H315 - H319 - H335 - H360
Precautionary statements	P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Codes	T
Risk Statements	46-60-61-36/37/38
Safety Statements	53-22-26-36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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